Influence of CYP3A4, CYP3A5 and MDR-1 polymorphisms on tacrolimus pharmacokinetics and early renal dysfunction in liver transplant recipients

作者: Yunying Shi , Yi Li , Jiangtao Tang , Junlong Zhang , Yuangao Zou

DOI: 10.1016/J.GENE.2012.10.048

关键词:

摘要: … ► The concentration/dose ratio of recipient with CYP3A5*1 homozygotes were lower. ► … role of CYP3A5, CYP3A4 and MDR-1SNPs on tacrolimus pharmacokinetics and their effect on …

参考文章(23)
V. Haufroid, P. Wallemacq, V. VanKerckhove, L. Elens, M. De Meyer, D. C. Eddour, J. Malaise, D. Lison, M. Mourad, CYP3A5 and ABCB1 polymorphisms and tacrolimus pharmacokinetics in renal transplant candidates: guidelines from an experimental study. American Journal of Transplantation. ,vol. 6, pp. 2706- 2713 ,(2006) , 10.1111/J.1600-6143.2006.01518.X
Ergun Velidedeoglu, Roy D. Bloom, Michael D. Crawford, Niraj M. Desai, Luis Campos, Peter L. Abt, Joseph W. Markmann, Kevin C. Mange, Kim M. Olthoff, Abraham Shaked, James F. Markmann, Early kidney dysfunction post liver transplantation predicts late chronic kidney disease. Transplantation. ,vol. 77, pp. 553- 556 ,(2004) , 10.1097/01.TP.0000114609.99558.41
Salim Fredericks, Michelle Moreton, Sandrine Reboux, Nicholas D. Carter, Lawrence Goldberg, David W. Holt, Iain A. M. MacPhee, Multidrug resistance gene-1 (MDR-1) haplotypes have a minor influence on tacrolimus dose requirements. Transplantation. ,vol. 82, pp. 705- 708 ,(2006) , 10.1097/01.TP.0000234942.78716.C0
Nicolas Picard, Pierre Marquet, The influence of pharmacogenetics and cofactors on clinical outcomes in kidney transplantation. Expert Opinion on Drug Metabolism & Toxicology. ,vol. 7, pp. 731- 743 ,(2011) , 10.1517/17425255.2011.570260
Jing Li, Bin Liu, Lu-Nan Yan, Lan-Lan Wang, Wan Y Lau, Bo Li, Wen-Tao Wang, Ming-Qing Xu, Jia-Yin Yang, Fu-Gui Li, None, Microproteinuria for detecting calcineurin inhibitor-related nephrotoxicity after liver transplantation World Journal of Gastroenterology. ,vol. 15, pp. 2913- 2917 ,(2009) , 10.3748/WJG.15.2913
Mary F Hebert, Amy LS Dowling, Cynthia Gierwatowski, Yvonne S Lin, Karen L Edwards, Connie L Davis, Christopher L Marsh, Erin G Schuetz, Kenneth E Thummel, Association between ABCB1 (multidrug resistance transporter) genotype and post-liver transplantation renal dysfunction in patients receiving calcineurin inhibitors. Pharmacogenetics. ,vol. 13, pp. 661- 674 ,(2003) , 10.1097/00008571-200311000-00002
Stefan Schaub, Michael Mayr, Gideon H??nger, Jennifer Bestland, J??rg Steiger, Axel Regeniter, Michael J. Mihatsch, John A. Wilkins, David Rush, Peter Nickerson, Detection of subclinical tubular injury after renal transplantation: comparison of urine protein analysis with allograft histopathology. Transplantation. ,vol. 84, pp. 104- 112 ,(2007) , 10.1097/01.TP.0000268808.39401.E8
Laure Elens, Rachida Bouamar, Dennis A Hesselink, Vincent Haufroid, Ilse P van der Heiden, Teun van Gelder, Ron HN van Schaik, A New Functional CYP3A4 Intron 6 Polymorphism Significantly Affects Tacrolimus Pharmacokinetics in Kidney Transplant Recipients Clinical Chemistry. ,vol. 57, pp. 1574- 1583 ,(2011) , 10.1373/CLINCHEM.2011.165613
L Renders, M Frisman, M Ufer, I Mosyagin, S Haenisch, U Ott, A Caliebe, M Dechant, F Braun, U Kunzendorf, I Cascorbi, CYP3A5 genotype markedly influences the pharmacokinetics of tacrolimus and sirolimus in kidney transplant recipients. Clinical Pharmacology & Therapeutics. ,vol. 81, pp. 228- 234 ,(2007) , 10.1038/SJ.CLPT.6100039
Giuseppe D'Amico, Claudio Bazzi, Urinary protein and enzyme excretion as markers of tubular damage. Current Opinion in Nephrology and Hypertension. ,vol. 12, pp. 639- 643 ,(2003) , 10.1097/01.MNH.0000098771.18213.A6