Multiple caffeine doses maintain vigilance during early morning operations.

摘要: Introduction: When used to counteract the effects of sleep deprivation, multiple doses caffeine are typically ingested across an extended period time. The goal this study was determine optimal dose for sustaining performance during loss with administration doses. Methods: There were 48 subjects (28 men, 20 women) who randomly assigned 1 4 groups (placebo, 50, 100, or 200 mg caffeine). After overnight 8-h period, required remain awake ensuing 29 h. Control data collected until 03:00 (Day 3), followed by three 2-h test blocks. At 03:00, 05:00, and 07:00 chewed two sticks gum (Stay Alert® chewing gum) containing placebo. Six 10-min sessions on a version Psychomotor Vigilance Test (PVT) completed each block. Stanford Sleepiness Scale (SSS) administered after PVT. Results: Lapses PVT categorized as response times greater than 1, 3, 5 s. in all categories significantly increased placebo group. Caffeine reduced number lapses dose-related manner; maintained at baseline levels entire caffeine. significant main effect session SSS, score increasing over time, but no differences between groups. Discussion: These results indicate that bi-hourly maintains vigilance single night without sleep.