Assessment of plasminogen activator inhibitor-1(PAI-1) biomarker in women with breast cancer disease

作者: Zahraa Mohammed AL-Nafakh , Arshad Noori G. AL-Dujaili , Ammar Rasoul Mohammed Rudha

DOI: 10.1063/5.0029591

关键词:

摘要: Breast cancer (BC) is the second close frequent most cancers among women, afterwards pores and skin cancer. It near typically determined of ladies used fifty five in conformity with 64 The aim concerning current education accordance consider plasminogen activator inhibitor-1 biomarker, additionally measured rapport this biomarker or some parameters include: distressed diagnosis, youth, stage, par yet physique substance index between girls mamma disease. Method: longevity existing study blanketed fifty- patients over AL-Najaf diagnosed along breast samples have been stability pulled beside sufferers when presence AL-forat Al-Awsat center metropolis because checking then treating course length prolonged from1/12/2018 to2/3/2019. healthy team namely power was once drawn up thirty -five (35) show as like were accrued beyond laboratory pathological analyzes within AL-Ashraf one-of-a-kind times. Long time healthful crew had matched affected person ages. ( 5 ml) about venous blood stretched out at 9-12 A.M ante cubital venipuncture use a disposable tine plastic syringes. Results: effects indicated widespread expand (P 0.05) according after their BMI.

参考文章(72)
Talieh Malek-Shahabi, Saeideh Esmaeili, Ali Malekshahi-Moghadam, Sayed Hossain Davoodi, Roghieh Shahbazi, Obesity as an important risk factor for certain types of cancer. Iranian journal of cancer prevention. ,vol. 6, pp. 186- 194 ,(2013)
Neill Patani, Lesley-Ann Martin, Mitch Dowsett, Biomarkers for the clinical management of breast cancer: international perspective. International Journal of Cancer. ,vol. 133, pp. 1- 13 ,(2013) , 10.1002/IJC.27997
Sarah A. Andres, Angelena B. Edwards, James L. Wittliff, Expression of Urokinase‐Type Plasminogen Activator (uPA), its Receptor (uPAR), and Inhibitor (PAI‐1) in Human Breast Carcinomas and Their Clinical Relevance Journal of Clinical Laboratory Analysis. ,vol. 26, pp. 93- 103 ,(2012) , 10.1002/JCLA.21488
Claudia Wolff, Katharina Malinowsky, Daniela Berg, Kerstin Schragner, Tibor Schuster, Axel Walch, Holger Bronger, Heinz Höfler, Karl-Friedrich Becker, Signalling networks associated with urokinase-type plasminogen activator (uPA) and its inhibitor PAI-1 in breast cancer tissues: new insights from protein microarray analysis† The Journal of Pathology. ,vol. 223, pp. 54- 63 ,(2011) , 10.1002/PATH.2791
Birgitte Vrou Offersen, Jan Alsner, Karen Ege Olsen, Rikke Riisbro, Nils Brünner, Flemming Brandt Sørensen, Boe Sandahl Sørensen, Birgitte Olrik Schlemmer, Jens Overgaard, , A comparison among HER2, TP53, PAI-1, angiogenesis, and proliferation activity as prognostic variables in tumours from 408 patients diagnosed with early breast cancer. Acta Oncologica. ,vol. 47, pp. 618- 632 ,(2008) , 10.1080/02841860801958295
Xiao-yu Pan, Yan Wang, Jie Su, Gao-xiang Huang, Dong-mei Cao, Shen Qu, Jian Lu, The mechanism and significance of synergistic induction of the expression of plasminogen activator inhibitor-1 by glucocorticoid and transforming growth factor beta in human ovarian cancer cells. Molecular and Cellular Endocrinology. ,vol. 407, pp. 37- 45 ,(2015) , 10.1016/J.MCE.2015.03.005
Minji Jo, Keena S. Thomas, Nadzeya Marozkina, Tanay J. Amin, Corinne M. Silva, Sarah J. Parsons, Steven L. Gonias, Dynamic assembly of the urokinase-type Plasminogen activator signaling receptor complex determines the mitogenic activity of urokinase-type Plasminogen activator Journal of Biological Chemistry. ,vol. 280, pp. 17449- 17457 ,(2005) , 10.1074/JBC.M413141200
Harvey W. Smith, Chris J. Marshall, Regulation of cell signalling by uPAR Nature Reviews Molecular Cell Biology. ,vol. 11, pp. 23- 36 ,(2010) , 10.1038/NRM2821
Jennifer C. Carter, Frank C. Church, Mature breast adipocytes promote breast cancer cell motility Experimental and Molecular Pathology. ,vol. 92, pp. 312- 317 ,(2012) , 10.1016/J.YEXMP.2012.03.005