Identification of isochromosome 1q as a recurring chromosome aberration in skull base chordomas: a new marker for aggressive tumors?

摘要: Object The authors conducted a study of 22 skull base chordomas. Methods A series chordomas was analyzed with G banding. Subsequently, metaphase cells obtained from three tumors were reexamined using multicolor spectral karyotyping. Clonal chromosome aberrations identified in 11 cases, all which recurrent tumors. Three showed remarkable similarity cytogenetic features, and these features appear to characterize recurring combination nonrandom aberrations, including isochromosome 1q, gain 7, monosomy for chromosomes 3, 4, 10,13, 18. Isochromosome 1q as the sole structural rearrangement pattern loss reported progression lumbosacral chordoma also appears be true additional findings Conclusions Skull characterized by 1q...