Desmethylimipramine (DMI) counteracts learned helplessness in rats.
作者： Alan I. Leshner , Helga Remler , Anat Biegon , David Samuel
DOI: 10.1007/BF00427633
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摘要: In a study of the mechanisms controlling learned helplessness phenomenon, rats were exposed to either inescapable preshocks or control procedures, treated with one three dosages desmethylimipramine, and tested for later adaptive responding. This catecholamine modulator attenuated deficits in escape responding that ordinarily follow prior exposure preshocks, it did so dose-dependent fashion. These findings support position helplessnes phenomenon is mediated by changes.
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