Study on the comparative immunogenicity of a recombinant DNA hepatitis B vaccine containing pre-S components of the HBV coat protein with non pre-S containing vaccines.
作者： I. YAP , R. GUAN , S. H. CHAN
DOI: 10.1111/J.1440-1746.1995.TB01047.X
关键词:
摘要: A new recombinant hepatitis B vaccine (SCI-B-VAC), derived from Chinese hamster ovary (CHO) cells and consisting of both the major S protein minor pre-S1 pre-S2 proteins viral coat were compared with two yeast-derived vaccines containing only (B-Hepavac II Engerix-B) for immunogenicity in human volunteers a randomized controlled study. Two hundred ninety-five healthy subjects completed 12 month follow up. There was no difference mean age sex distribution among three study groups. Seroconversion rates all groups similar at months 6, 9 12. However, surface antibody (anti-HBs) geometric titres (GMT) significantly higher 10 micrograms SCI-B-VAC 20 Engerix-B than B-Hepavac-II 6 also showed anti-HBs GMT (295 vs 143 miu/mL, P < 0.02).
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