Tissue microscopic changes and artifacts in multi-phase post-mortem computed tomography angiography in a hospital setting: a fatal case of systemic vasculitis.

摘要: A 27-year-old man suddenly died in hospital of acute respiratory distress syndrome secondary to severe systemic vasculitis. Multi-phase post-mortem computed tomography angiography followed by scientific autopsy the thoracic and abdominal cavity histology was performed, illustrating advantages drawbacks such techniques. Imaging enabled us examine cranium, as family refused cerebral dissection. MPMCTA revealed absence opacification left middle artery. But parenchymal findings organs were still difficult interpret after both imaging macroscopic examination during autopsy. Microscopic provided definitive diagnosis cause death. Analysis vasculitis lung complicated diffuse alveolar, mediastinal, splenic retroperitoneal lesions. We unable determine type vasculitis, whether polyarteritis nodosa or microscopic polyangiitis, because artifactual glomerular collapse. observed some structural changes tissue contrast agent injection, affecting vascular system renal parenchyma particular. Such artifacts must be known order avoid misinterpreting them pathological findings. conventional are two complementary techniques showing their specific limits which have choose appropriate technique. One limit is detection can only obtained additional histological examination. This case report underlines this fact demonstrates that caution required cases if analyses carried out injection.