Psychomotor activity and body weight gain after exposure to low ribavirin doses in rats: Role of treatment duration

摘要: Paper description: Ribavirin is an antiviral agent showing side effects associated with use of high doses and/or long-term application. This study examined the single or repeated application low ribavirin (10, 20 and 30 mg/kg/day, i.p.) on dopamine-mediated behaviors, novelty-induced investigation d-amphetamine-induced motor activity, body weight gain in adult male rats. Hypolocomotion reduced a U-shaped dose-response related manner were observed after treatment. The findings contribute to improved understanding psychomotor physiological responses rodent model regard treatment duration. Abstract: Clinically-related basic studies behavioral are still lacking despite its wide as medication. paper considers mg/kg/day) activity (novelty-induced exploratory behavior, d-amphetamine (AMPH, 1.5 mg/kg, intraperitoneal)-induced activity), socially undisturbed Wistar rats 24 h first, seventh fourteenth once-a-day injection. Low tested attempt avoid recognized systemic high-dose usage. None singly applied affected exploratory/spontaneous AMPH-induced behavior (locomotion, stereotypy-like vertical however, was significantly lower mg/kg ribavirin. 7- 14-day treatments 10 mg/kg/day suppressed locomotion gain; at dose decreased stereotypy. These indicate that (up 14 days) results along gain, accentuating existence relationship prolonged duration https://doi.org/10.2298/ABS190205018P Received: February 5, 2019; Revised: March 13, Accepted: 22, Published online: 25, 2019 How cite this article: Petkovic B, Stojadinovic G, Kesic S, Ristic Martac Lj, Podgorac J, Pesic V. Psychomotor exposure rats: role Arch Biol Sci. 2019;71(2):357-68.