High-Power Phased-Array Transducer Module for the Construction of a System for the Treatment of Deep Vein Thrombosis

作者: Maryam Motmaen Dadgar , Kullervo Hynynen

DOI: 10.1109/TUFFC.2020.3011666

关键词:

摘要: Blood clot can be disintegrated by high-intensity focused ultrasound alone through inertial cavitation. There are limitations in using single-element transducers for this purpose such as lack of steerability and control the focus terms shape location. Phased-array being able to rapidly scan over clots alleviate problem. A full 3-D beam achieved 2-D electronically steerable arrays. However, required high-pressure amplitude has not been possible with In work, a 64-element fully populated phased-array transducer module was designed fabricated deep vein thrombosis (DVT). Lateral coupling considered design decrease electrical impedance eliminate need matching circuit. PZT-4 thickness 0.35 mm, an element surface area $2.2\,\,\text {mm} \times {2.2}$ length 6 mm showed mean 60.4 ± 11.5 measured each facilitating effective electric power transfer from driving electronics. No breakdown observed when voltage increased gradually 180 3 Vpp. Operation at Vpp found safe 10,000 repetitions without reduction power, resulting average pressure 1.01 0.09 MPa 2 surface. These values indicate that array eight modules (80 $\text {40}$ mm) is reach needed DVT. Such arrays practical current technology.

参考文章(22)
S.D. Sokka, J. Juste, K. Hynynen, Design and evaluation of broadband multi-channel ultrasound driving system for large scale therapeutic phased arrays ieee symposium on ultrasonics. ,vol. 2, pp. 1638- 1641 ,(2003) , 10.1109/ULTSYM.2003.1293224
Simone Park, Adam D. Maxwell, Gabe E. Owens, Hitinder S. Gurm, Charles A. Cain, Zhen Xu, Non-Invasive Embolus Trap Using Histotripsy—An Acoustic Parameter Study Ultrasound in Medicine and Biology. ,vol. 39, pp. 611- 619 ,(2013) , 10.1016/J.ULTRASMEDBIO.2012.11.026
Haiying Huang, Daniel Paramo, Broadband electrical impedance matching for piezoelectric ultrasound transducers IEEE Transactions on Ultrasonics Ferroelectrics and Frequency Control. ,vol. 58, pp. 2699- 2707 ,(2011) , 10.1109/TUFFC.2011.2132
Cameron Wright, Kullervo Hynynen, David Goertz, In vitro and in vivo high-intensity focused ultrasound thrombolysis. Investigative Radiology. ,vol. 47, pp. 217- 225 ,(2012) , 10.1097/RLI.0B013E31823CC75C
Adam D. Maxwell, Charles A. Cain, Alexander P. Duryea, Lingqian Yuan, Hitinder S. Gurm, Zhen Xu, Noninvasive Thrombolysis Using Pulsed Ultrasound Cavitation Therapy – Histotripsy Ultrasound in Medicine & Biology. ,vol. 35, pp. 1982- 1994 ,(2009) , 10.1016/J.ULTRASMEDBIO.2009.07.001
Adam D. Maxwell, Gabe Owens, Hitinder S. Gurm, Kimberly Ives, Daniel D. Myers, Zhen Xu, Noninvasive Treatment of Deep Venous Thrombosis Using Pulsed Ultrasound Cavitation Therapy (Histotripsy) in a Porcine Model Journal of Vascular and Interventional Radiology. ,vol. 22, pp. 369- 377 ,(2011) , 10.1016/J.JVIR.2010.10.007
Junho Song, Benjamin Lucht, Kullervo Hynynen, Large improvement of the electrical impedance of imaging and high-intensity focused ultrasound (HIFU) phased arrays using multilayer piezoelectric ceramics coupled in lateral mode IEEE Transactions on Ultrasonics Ferroelectrics and Frequency Control. ,vol. 59, pp. 1584- 1595 ,(2012) , 10.1109/TUFFC.2012.2358
R.L. Goldberg, S.W. Smith, Multilayer piezoelectric ceramics for two-dimensional array transducers IEEE Transactions on Ultrasonics Ferroelectrics and Frequency Control. ,vol. 41, pp. 761- 771 ,(1994) , 10.1109/58.308512
K. Hynynen, Jianhua Yin, Lateral mode coupling to reduce the electrical impedance of small elements required for high power ultrasound therapy phased arrays IEEE Transactions on Ultrasonics Ferroelectrics and Frequency Control. ,vol. 56, pp. 557- 564 ,(2009) , 10.1109/TUFFC.2009.1072
Samuel Z Goldhaber, Henri Bounameaux, Pulmonary embolism and deep vein thrombosis The Lancet. ,vol. 379, pp. 1835- 1846 ,(2012) , 10.1016/S0140-6736(11)61904-1