THE HYDROGENOLYSIS OF 3-HYDROXYMETHYLINDOLE AND OTHER INDOLE DERIVATIVES WITH LITHIUM ALUMINUM HYDRIDE
作者： Edward Leete , Léo Marion
DOI: 10.1139/V53-106
关键词:
摘要: Indole-3-aldehyde, indole-3-carboxylic acid and its ethyl ester were reduced by excess lithium aluminum hydride to skatole. The expected reduction product, 3-hydroxymethylindole, was obtained the action of sodium hydroxide on gramine methiodide. It alkyl ethers readily 3-Hydroxymethylindole underwent self-condensation 3,3′-di-indolylmethane in neutral alkaline media, with acidic reagents converted an oxygen-free polymeric substance. mechanism these reactions hydrogenolysis is discussed
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