Synthesis, structural characterization, solution behavior, and in vitro antiproliferative properties of a series of gold complexes with 2-(2'-pyridyl)benzimidazole as ligand: comparisons of gold(III) versus gold(I) and mononuclear versus binuclear derivatives.
作者： Ida Landini , Stefania Nobili , Enrico Mini , Luigi Messori , Maria Serratrice
DOI: 10.1021/IC202639T
关键词:
摘要: A variety of gold(III) and gold(I) derivatives 2-(2′-pyridyl)benzimidazole (pbiH) were synthesized fully characterized their antiproliferative properties evaluated in a representative ovarian cancer cell line. The complexes include the mononuclear species [(pbi)AuX2] (X = Cl, 1; OAc, 2), [(pbiH)AuCl] (3), [(pbiH)Au(PPh3)][PF6] (4-PF6), [(pbi)Au(L)] (L PPh3, 5; TPA, 6), binuclear gold(I)/gold(I) gold(I)/gold(III) [(PPh3)2Au2(μ2-pbi)][PF6] (10-PF6), [ClAu(μ3-pbi)AuCl2] (7),and [(PPh3)Au(μ3-pbi)AuX2][PF6] 8-PF6; 9-PF6). molecular structures 6, 7, 10-PF6 determined by X-ray diffraction analysis. chemical behavior these compounds solution was analyzed both cyclic voltammetry DMF absorption UV–vis spectroscopy an aqueous buffer. Overall, stability gold found to be acceptable for cellular studies. For all complexes, relevant activities vitro documented against A27...
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