Indolpyruvic acid administration increases the brain content of kynurenic acid

摘要: Abstract The possibility of changing the tissue content kynurenic acid (KYNA), a tryptophan metabolite which acts as an antagonist excitatory amino receptors, was investigated by measuring its concentration in brain, blood, liver and kidney rats using specific method based on ion exchange chromatography HPLC. administration (TRP) or keto analogue, indolpyruvic (IPA) (50–500 mg/kg i.p.), significantly increased, dose-dependent manner, KYNA various organs, including brain. increased brain after IPA could not be completely explained considering that may transaminated to TRP enzymes leading from are known. An alternative pathway synthesis therefore proposed. These findings indicate it is possible change endogenous glutamate antagonist. This new avenue modulate vivo receptors.