Homocysteine trials--clear outcomes for complex reasons.

摘要: In 1969, McCully first proposed that homocysteine causes atherosclerosis.1 His hypothesis was based on the finding of atherosclerotic plaque at autopsies young people with homocystinuria. This later modified to include a broader population, positing mild hyperhomocysteinemia caused by dietary deficiencies vitamin cofactors required for metabolism — folic acid, B12, and B6 is risk factor atherothrombosis. developed countries, these vitamins are partially removed from foods during processing,2 typical diets rich in precursor amino acid methionine (which derived animal . . .