Human monocytes convert leukotriene B4 to two dihydro-leukotriene B4-metabolites
作者： J. Fauler , K-H Marx , V. Kaever , J.C. Frölich
DOI: 10.1016/0952-3278(89)90085-9
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摘要: Abstract Human monocytes metabolize LTB4 by an additional pathway different from omega-oxidation. Reverse-phase high performance liquid chromatography showed four metabolites: 20-COOH-LTB4, 20-OH-LTB4 and two metabolites less polar than with UV maximum at 232 nm. Gaschromatography mass-spectrometry nearly identical mass spectra for both metabolites. The main fragments of the were increased units compared to LTB4. Our findings suggest that had been reduced a known new dihydro-metabolite Both together amounted 85% total remaining 15% omega-oxidation products. Thus, major metabolism human is reduction dihydro-LTB4.
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