Persistent infection of hepatitis E virus transmitted by blood transfusion in a patient with T-cell lymphoma.
作者： Akinori Tamura , Yohko K. Shimizu , Torahiko Tanaka , Kazumichi Kuroda , Yasuyuki Arakawa
DOI: 10.1111/J.1872-034X.2007.00024.X
关键词:
摘要: Aim With advent of reverse-transcription (RT)/polymerase chain reaction (PCR) for detection the hepatitis E viral genome, we carried out retrospective examinations. Methods Serum samples collected from 68 patients diagnosed as with unknown etiology were tested markers virus. Results Two them found positive RNA. While clinical course one patient (patient 1) was typical acute E, another 2) persistently infected HEV. Patient 2 virus via blood transfusion during chemotherapy against T-cell lymphoma. The entire genome donor identical that serum obtained on day 170 after implicated red cell (RBC) product, confirming transmission HEV by transfusion. remained negative anti-HEV antibodies follow-up period six months, probably due to immune suppression lymphoma and chemotherapy. Conclusion We report here an unusual case long-term infection in a Persistent absence antibodies, which caused
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