A pooled data analysis on the use of intermittent cyclical etidronate therapy for the prevention and treatment of corticosteroid induced bone loss.

摘要: Objective. To conduct a pooled data analysis in group of patients defined by sex, menopausal status, and underlying disease order to examine the effect intermittent cyclical etidronate prevention treatment corticosteroid induced osteoporosis. Methods. We selected 5 randomized, placebo controlled studies that examined efficacy therapy which raw were available for analysis. Three 2 studies. The primary outcome was difference between groups percentage change from baseline lumbar spine bone density. Secondary outcomes included femoral neck trochanter density, vertebral fracture rates. Results. Results are separately had significant mean differences (95% CI) spine, neck, density 3.7 (2.6 4.7), 1.7 (0.4 2.9), 2.8% (1.3 4.2) after one year treatment, favor group. displayed 4.8 (2.7 6.9) 5.4% (2.5 8.4) years therapy. In studies, reduced incidence observed compared with (relative risk 0.50; CI 0.21 1.19). Conclusion. Etidronate effective preventing loss or slightly increasing mass A benefit postmenopausal women treated