MK801 induces late regional increases in NMDA and kainate receptor binding in rat brain.
作者： X. -M. Gao , C. A. Tamminga
DOI: 10.1007/BF01271549
关键词:
摘要: We have previously shown that a single dose of PCP produces dose-related increase in NMDA-sensitive 3H-glutamate binding CA1 hippocampus 24 hours later, and some regional changes kainate binding. Here we report dizocilpine (MK 801) (0.1 mg/kg 1 mg/kg), selective agonist at the receptor noncompetitive antagonist NMDA, similar glutamate after dose. These observations support conclusion blockade glutamate-mediated transmission NMDA selectively increases CA3 dentate gyrus putatively delayed time points. Several additional areas outside also showed MK801.
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