Genes and microRNAs associated with mouse cleft palate: A systematic review and bioinformatics analysis

摘要: Cleft palate (CP) is the most prevalent craniofacial deformity, with ethnic and geographic variation in prevalence humans. Mice have been used as an animal model to study cause(s) of CP by several approaches, including genetic chemical-induced approaches. Mouse approaches revealed that significant amounts genes are involved pathology. The aim this was identify common features CP-associated explore roles microRNAs (miRNAs) important post-transcriptional regulators may be regulation genes. To generate accurate list associated CP, we first conducted systematic literature searches through main databases such Medline, Embase, PubMed, well other sources Scopus Genome Informatics. We found 195 mouse strains single-gene mutations 140 compound-gene were reported CP. categorized functions pathways using Kyoto Encyclopedia Genes Genomes Gene Ontology annotations, highlighting contribution cellular metabolism A total 18 miRNAs multiple Human genotype-phenotype analysis variants five human homologous (IRF6, FOXE1, VAX1, WNT9B, GAD1) significantly contributed phenotype. Thus, our results suggest play role networks crucial for palatal formation.