CRMPs: critical molecules for neurite morphogenesis and neuropsychiatric diseases.
作者： T T Quach , J Honnorat , P E Kolattukudy , R Khanna , A M Duchemin
DOI: 10.1038/MP.2015.77
关键词:
摘要: Neuronal polarity and spatial rearrangement of neuronal processes are central to the development all mature nervous systems. Recent studies have highlighted dynamic expression Collapsin-Response-Mediator Proteins (CRMPs) in dendritic/axonal compartments, described their interaction with cytoskeleton proteins, identified ability activate L- N-type voltage-gated calcium channels (VGCCs) delineated crucial role as signaling molecules essential for neuron differentiation neural network maintenance. In addition, evidence obtained from genome-wide/genetic linkage/proteomic/translational approaches revealed that CRMP is altered human pathologies including mental (schizophrenia mood disorders) neurological (Alzheimer's, prion encephalopathy, epilepsy others) disorders. Changes CRMPs levels been observed after psychotropic treatments, disrupting CRMP2 binding blocked neuropathic pain. These observations, altogether those genetically modified mice targeting individual RNA interference approaches, pave way considering potential early disease markers modulation activity therapeutic strategy disorders associated neurite abnormalities.
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