Progression of dopaminergic degeneration in Parkinson's disease and atypical parkinsonism: A longitudinal β-CIT SPECT study

摘要: Atypical parkinsonian syndromes (APS) such as multiple system atrophy, progressive supranuclear palsy, and corticobasal degeneration are characterized by poor response to antiparkinsonian medication rapid clinical deterioration. We used SPECT [123I]beta-CIT a label of dopamine transporters study the progression presynaptic dopaminergic in Parkinson's disease (PD) APS. Twenty-four PD patients with short duration (2.4 +/- 1.5 years), 12 long (9.2 2.6 10 APS (disease 2.1 nine essential tremor (ET) underwent sequential imaging an interval 25.5 10.3 (13-63) months. The age-related decline striatal beta-CIT binding was studied cross-sectionally 30 healthy subjects. ratio striatum/cerebellum -1 at 20 hours after tracer injection, reflecting specific-to-nondisplaceable binding, primary outcome measure. At scan 1, reduced (-42% compared age-corrected normal values) (-51%), (-36%), but ET. During observation period significantly declined (14.9% per year) (7.1% year), whereas ET showed no significant change between scans 1 2. relative annual reduction from values time higher than (9.6 vs. 4.3%, P = 0.004). These results demonstrate atypical syndromes, exceeding PD. appears slow down during course disease. is sensitive marker disorders.