Pulse of α-2-macroglobulin and lipocalin-1 in the pregnant uterus of European polecats (Mustela putorius) at the time of implantation

摘要: Uterine secretory proteins protect the uterus and conceptuses against infection, facilitate implantation, control cellular damage resulting from supply embryos with nutrients. The early conceptus of European polecat (Mustela putorius) grows develops free in until implanting at about 12 days after mating. Using a proteomics approach we found that appearing leading up to including time implantation changed dramatically time. Several identified have been pregnant uteri other placental mammals, such as α1-antitrypsin, serum albumin, lactoferrin, cathepsin L1, uteroferrin, ectonucleotide pyrophosphatase. broad-spectrum proteinase inhibitor α2-macroglobulin rose relatively low abundance initially dominate protein profile by implantation. Its functions may be limit caused release proteinases during processes around site Lipocalin-1 (also known tear lipocalin) has not previously recorded uterine secretion pregnancy, also increased substantially concentration. If lipocalin-1 similar biochemical properties human form, then it combined function transporting or scavenging lipids, antimicrobial activities. changes proteome Euroepan polecats those species mustelid engage embryonic diapause, but possibly only following reactivation embryo.