Phenotypic Expression of Transformation: Induction in Cell Culture by a Phorbol Ester
作者： A. Sivak , B. L. Van Duuren
DOI: 10.1126/SCIENCE.157.3795.1443
关键词:
摘要: A biologically potent, tumor-promoting phorbol ester from Croton tiglium L. induces the appearance of transformed clones in a population contact-inhibited fibroblasts mouse cell line 3T3. Mixed populations cells with 10,000 3T3 and 100 virus-transformed were exposed to and, comparison untreated cells, showed marked increase numbers that grew. Exposure cultures carcinogen 7,12-dimethylbenz(a)anthracene alone or prior exposure did not cause any number clones.
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L. Orris, A. Sivak, L. Langseth, B. L. Van Duuren, The tumor-enhancing principles of Croton tiglium L. II. A comparative study. Cancer Research. ,vol. 26, pp. 1729- 1733 ,(1966)
L. Orris, B. L. Van Duuren, The Tumor-enhancing Principles of Croton Tiglium L. Cancer Research. ,vol. 25, pp. 1871- 1875 ,(1965)
E. M. Levine, Y. Becker, C. W. Boone, H. Eagle, CONTACT INHIBITION, MACROMOLECULAR SYNTHESIS, AND POLYRIBOSOMES IN CULTURED HUMAN DIPLOID FIBROBLASTS. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 53, pp. 350- 356 ,(1965) , 10.1073/PNAS.53.2.350
George J. Todaro, Howard Green, High frequency of SV40 transformation of mouse cell line 3T3 Virology. ,vol. 28, pp. 756- 759 ,(1966) , 10.1016/0042-6822(66)90261-3
G. J. Todaro, H. Green, Cell growth and the initiation of transformation by SV40. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 55, pp. 302- 308 ,(1966) , 10.1073/PNAS.55.2.302
Alice Goldé, Chemical changes in chick embryo cells infected with Rous sarcoma virus in vitro Virology. ,vol. 16, pp. 9- 20 ,(1962) , 10.1016/0042-6822(62)90197-6
G. J. Todaro, H. Green, Successive Transformations of an Established Cell Line by Polyoma Virus and SV40 Science. ,vol. 147, pp. 513- 514 ,(1965) , 10.1126/SCIENCE.147.3657.513
G. J. Todaro, H. Green, B. D. Goldberg, TRANSFORMATION OF PROPERTIES OF AN ESTABLISHED CELL LINE BY SV40 AND POLYOMA VIRUS. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 51, pp. 66- 73 ,(1964) , 10.1073/PNAS.51.1.66
R. Dulbecco, G. Freeman, Plaque production by the polyoma virus Virology. ,vol. 8, pp. 396- 397 ,(1959) , 10.1016/0042-6822(59)90043-1
George J. Todaro, Howard Green, QUANTITATIVE STUDIES OF THE GROWTH OF MOUSE EMBRYO CELLS IN CULTURE AND THEIR DEVELOPMENT INTO ESTABLISHED LINES Journal of Cell Biology. ,vol. 17, pp. 299- 313 ,(1963) , 10.1083/JCB.17.2.299