The Importance of Antibiotic Pharmacokinetics in Critical Illness

摘要: Antibiotics are the most commonly used drugs in surgical patient. Pharmacokinetics is study of processes that result delivery to effector sites. Drug absorption, distribution, biotransformation, and excretion critical elements drug The biologic elimination half-life (t1/2) volume distribution (Vd) terms describe active pharmacokinetics; t1/2 Vd determined for antibiotics by employing healthy volunteers or minimally ill patients. From these data, dosing schedules each antibiotic determined. This article reviews literature on impact illness sepsis pharmacokinetics. data identify may be reduced hyperdynamic states stress expanded. These changes mean currently accepted regimens critically patients inadequate. Subtherapeutic concentrations account treatment failures significance emergence bacterial resistance.