Mutagenicity of Pesticides: Concepts and Evaluation

摘要: "There are now about 400 substances that, in various forms and combinations, used as pesticides. It is feasible to test all of these the near future for mutagenicity systems that simple precise, yet relevant man."Mutation defined this book any inherited alteration genetic material which generations may lead a wide range irreversible abnormalities. There growing concern chemical mutagens not only pose potential public health hazard, but some chemicals constitute great risk radiation--possibly more serious one. This first present recently developed mammalian methodologies evaluating mutagenic hazards such The authors explain most cases it initial compound metabolic products pesticide will cause trouble. critical needs data toxicologic testing general particular was emphasized by Dr. Joshua Lederberg foreword...".we can calculate at least 25 percent our burden origin. figure very conservative estimate view component griefs schizophrenia, diabetes, atherosclerosis, mental retardation, early senility man congenital malformations. In fact, factor disease bound increase an even larger proportion, we deal with infectious other environmental insults, legacy species compete traumatic accidents major health.... Given how many new, suspicious compounds pervade environment, face formidable task putting house order."This study based on Report Advisory Panel Mutagenicity Pesticides Secretary's Commission their Relationship Environmental Health. composed internationally recognized authorities mutagenesis, toxicology. has been greatly modified since original HEW report (1969) includes tabulations cross index 370 pesticides listed common names synonyms, name formula (illustrated), uses, manufacturers. also literature review pesticide, organism tested, assay system, range, effective minimum dose, biological effect. For example: CAPTAN (orthocide) protectant eradicant fungicide fruits, vegetables, flowers control scabs, blotches, rots, mildews. manufactured Stauffer Chevron. When tested human embryo cells (L-132 cells, 10 mcg/ml) effected inhibition DNA synthesis.In addition, covers structure-activity relations usage patterns pesticides, recommends program mutagenesis testing, contains summary well bibliography related effects compounds.