Tolerance and Sensitization to the Effects of Antipsychotic Drugs on Dopamine Transmission

摘要: Beginning with the finding by Carlsson and Lindqvist (1963) that acute administration of chlorpromazine increases dopamine (DA) turnover, an extensive literature has developed concerning effects antipsychotic drug (APD) on multiple brain DA systems. Although APDs different chemical classes can vary markedly in their molecular structure receptor binding profiles (Hyttel et al. 1985), they all act to some degree as antagonists (Seeman 1976; Farde 1988). A wide variety neuronal mechanisms have been studied relation prolonged APD dopaminergic function, including changes receptors, receptor-linked second messenger activity, neuron electrophysiology (See Chapman 1994, for review). Among many release turnover forebrain continues serve primary reflection dynamic APD-induced alterations neural activity. One aim present chapter is review findings metabolism.