Antioxidants and Oxidative Stress: Focus in Obese Pregnancies.

摘要: The prevalence of obesity in women childbearing age around the globe has dramatically increased last decades. Obesity is characterized by a low-state chronic inflammation, metabolism impairment and oxidative stress, among other pathological changes. Getting pregnant this situation involves that gestation will occur an unhealthy environment, can potentially jeopardize both maternal fetal health. In review, we analyze role obesity-induced stress as risk factor to develop adverse outcomes during gestation, including reduced fertility, spontaneous abortion, teratogenesis, preeclampsia, intrauterine growth restriction. Evidences macromolecule oxidation increase reactive oxygen species generation antioxidant defense alterations are commonly described tissues. Thus, supplementation become interesting prophylactic therapeutic tool, yields positive results cellular, animal models. However, from most meta-analysis studying effect these therapies complicated gestations humans not really encouraging. It still be analyzed whether could work if applied cohorts patients at high risk, such those with low concentration antioxidants or obese women.