Malondialdehyde and superoxide dismutase correlate with FEV1 in patients with COPD associated with wood smoke exposure and tobacco smoking.

摘要: Tobacco smoking is the primary risk factor for chronic obstructive pulmonary disease (COPD). However, recent epidemiological studies have established domestic exposure to wood smoke and other biomass fuels as additional important factors, characteristic in developing countries. Oxidative stress one of mechanisms concerned with pathogenesis COPD. molecular involved onset progress COPD associated specifically that derived from remain unknown. We analyzed relationship between forced expiratory volume first second (FEV(1)) plasma malondialdehyde (MDA) concentration activities superoxide dismutase (SOD), glutathione peroxidase (GPx), reductase (GR), glutathione-S-transferase (GST) patients (WSG; n = 30), tobacco (TSG; healthy control subjects (HCG; 30). Differences FEV(1) WSG TSG (58 +/- 22% 51 24%, respectively) HCG (100 6%) were observed (P < 0.01). Plasma MDA was higher both (1.87 0.81 1.68 0.82 nmol/mL, compared (0.42 0.17 nmol/mL; P SOD activity showed a significant increase (0.36 0.12 0.37 0.13 U/mL) (0.19 0.04 U/mL; No differences shown regarding GPx, GR, GST groups. Inverse correlations founded 0.001). These results indicate role oxidative similar who ceased at least 10 years previous this study.