Renal-specific actions of angiotensin II receptor antagonism in the anesthetized dog

摘要: The role of angiotensin II (AII) in the regulation systemic hemodynamic and renal function sodium excretion, although important states characterized by activation renin-angiotensin system, remains unclear under basal conditions. current studies were designed to define AII cardiovascular using a specific receptor antagonist, DuP 753, normal anesthetized dog. No changes mean arterial pressure, cardiac output, or vascular resistance observed during infusion 753. In contrast, significant increase glomerular filtration rate (19.7 +/- 0.9 26.1 2.0 mL/min) blood flow (151 20 188 26 mL/min), with decrease (0.85 0.10 0.66 0.06 mm Hg/mL/min) was observed. Associated changes, diuretic (0.16 0.05 0.57 0.21 natriuretic (31.2 7.0 100.5 22.2 microEq/min) response also demonstrated. Renal associated tubular reabsorption an fractional excretion (1.10 0.3 2.61 0.62%), whole-kidney proximal indicated lithium 2.2 40.8 3.9%). addition, kaliuretic (17.9 2.1 27.1 2.4 despite concurrent plasma aldosterone (10.8 1.5 8.1 1.0 ng/dL).(ABSTRACT TRUNCATED AT 250 WORDS)