Taspine derivative TAS9 regulates cell growth and metastasis of human hepatocellular carcinoma
作者： RUI LIU , WENJIE WANG , BINGLING DAI , YANPING LIU , YANMIN ZHANG
关键词:
摘要: Taspine has been indicated to be a potential anti‑carcinogenic agent. The present study investigated the effects of TAS9, modified taspine derivative, on proliferation and migration SMMC‑7721 human liver cancer cell line. First, TAS9 growth were examined using MTT colony formation assaya. In vivo Transwell wound healing assays then performed assess inhibitory invasion migration, respectively. expression proliferation‑ migration‑associated signaling molecules was by western blot analysis. results that inhibited downregulating protein kinase Cβ (PKCβ), Akt, mammalian target rapamycin, mitogen‑activated 2, RAF c‑Jun N‑terminal kinase‑1, inhibiting suppressing matrix metalloproteinase (MMP)‑2, MMP‑9, chemokine (C‑X‑C motif) receptor 4, nuclear factor κB, p38 p53. Small interfering RNA‑mediated knockdown PKCβ in cells significantly attenuated tumor TAS9. conclusion, suggested may have cells, serve as candidate for treatment.
spandidospublications.org参考文章(33)
Kurt W. Kohn, Joany Jackman, Ian Magrath, Kishor Bhatia, Daniel Jondle, Patrick M. O'Connor, Role of the p53 tumor suppressor gene in cell cycle arrest and radiosensitivity of Burkitt's lymphoma cell lines Cancer Research. ,vol. 53, pp. 4776- 4780 ,(1993)
Chao-Zhong Song, Yangchao Chen, George Stamatoyannopoulos, Down-regulation of CXCR4 by inducible small interfering RNA inhibits breast cancer cell invasion in vitro. Cancer Research. ,vol. 63, pp. 4801- 4804 ,(2003)
A Philippi, E Roschmann, F Tores, P Lindenbaum, A Benajou, L Germain-Leclerc, C Marcaillou, K Fontaine, M Vanpeene, S Roy, S Maillard, V Decaulne, J P Saraiva, P Brooks, F Rousseau, J Hager, Haplotypes in the gene encoding protein kinase c-beta (PRKCB1) on chromosome 16 are associated with autism Molecular Psychiatry. ,vol. 10, pp. 950- 960 ,(2005) , 10.1038/SJ.MP.4001704
Yanmin Zhang, Langchong He, Liang Meng, Wenjuan Luo, Xuemei Xu, Suppression of tumor-induced angiogenesis by taspine isolated from Radix et Rhizoma Leonticis and its mechanism of action in vitro. Cancer Letters. ,vol. 262, pp. 103- 113 ,(2008) , 10.1016/J.CANLET.2007.11.035
Sandrine Faivre, Guido Kroemer, Eric Raymond, Current development of mTOR inhibitors as anticancer agents Nature Reviews Drug Discovery. ,vol. 5, pp. 671- 688 ,(2006) , 10.1038/NRD2062
Judith M. Rollinger, Daniela Schuster, Elisabeth Baier, Ernst P. Ellmerer, Thierry Langer, Hermann Stuppner, Taspine: bioactivity-guided isolation and molecular ligand-target insight of a potent acetylcholinesterase inhibitor from Magnolia x soulangiana. Journal of Natural Products. ,vol. 69, pp. 1341- 1346 ,(2006) , 10.1021/NP060268P
M. Hidalgo, S. G. Eckhardt, Development of Matrix Metalloproteinase Inhibitors in Cancer Therapy Journal of the National Cancer Institute. ,vol. 93, pp. 178- 193 ,(2001) , 10.1093/JNCI/93.3.178
Guru-Dutt Sharma, Jiucheng He, Haydee E. P. Bazan, p38 and ERK1/2 Coordinate Cellular Migration and Proliferation in Epithelial Wound Healing EVIDENCE OF CROSS-TALK ACTIVATION BETWEEN MAP KINASE CASCADES Journal of Biological Chemistry. ,vol. 278, pp. 21989- 21997 ,(2003) , 10.1074/JBC.M302650200
C Zhen, L Chen, Q Zhao, B Liang, Y-X Gu, Z-f Bai, K Wang, X Xu, Q-y Han, D-f Fang, S-x Wang, T Zhou, Q Xia, W-l Gong, N Wang, H-Y Li, B-F Jin, J-h Man, Gankyrin promotes breast cancer cell metastasis by regulating Rac1 activity. Oncogene. ,vol. 32, pp. 3452- 3460 ,(2013) , 10.1038/ONC.2012.356
Hongping Gao, Ping Su, Yaling Shi, Xiuxiu Shen, Yanmin Zhang, Jinyun Dong, Jie Zhang, Discovery of novel VEGFR-2 inhibitors. Part II: biphenyl urea incorporated with salicylaldoxime. European Journal of Medicinal Chemistry. ,vol. 90, pp. 232- 240 ,(2015) , 10.1016/J.EJMECH.2014.11.032