Efficacy of progesterone for moderate to severe traumatic brain injury: a meta-analysis of randomized clinical trials.

摘要: Progesterone has been shown to have neuroprotective effects in multiple animal models of brain injury, whereas the efficacy and safety patients with traumatic injury (TBI) remains contentious. Here, a total seven randomized controlled trials (RCTs) 2492 participants were included perform this meta-analysis. Compared placebo, there was no significant decrease be found rate death or vegetative state for acute TBI (RR = 0.88, 95%CI = 0.70, 1.09, p = 0.24). Furthermore, progesterone not associated good recovery comparison placebo (RR = 1.00, 95%CI = 0.88, 1.14, p = 0.95). Together, our study suggested that did improve outcomes over treatment TBI.