Inflammation meets cancer, with NF-κB as the matchmaker

摘要: Inflammation is a fundamental protective response that sometimes goes awry and becomes major cofactor in the pathogenesis of many chronic human diseases, including cancer. Here we review evolutionary relationship opposing functions transcription factor NF-κB inflammation Although it seems to fulfill distinctly tumor-promoting role types cancer, has confounding certain tumors. Understanding activity function context tumorigenesis critical for its successful taming, an important challenge modern cancer biology.