Increased Incidence of Resistant Hypertension in Patients With Systemic Lupus Erythematosus: A Retrospective Cohort Study

摘要: OBJECTIVE To compare the risk of resistant hypertension (RHTN) in patients with systemic lupus erythematosus (SLE) and controls without SLE, to define factors associated RHTN SLE. METHODS We studied 1,044 SLE 5,241 control subjects using de-identified electronic health records from a tertiary care center. was defined as ≥4 International Classification Diseases, Ninth Revision codes for antinuclear antibody titer ≥1:160. uncontrolled blood pressure on 3 antihypertensive medications or requiring 4 more antihypertensives attain control. First, we compared between groups. Second, examined association all-cause mortality RESULTS nearly twice prevalent (10.2% 5.3%, respectively), an incidence rate 10.2 versus 6.1 cases per 1,000 person-years observation (hazard ratio [HR] 1.72 [95% confidence interval 1.28-2.30]; P < 0.001, adjusted age, sex, race, baseline end-stage renal disease [ESRD], creatinine, calendar year). In found associations black lower function, hypercholesterolemia, increased inflammatory markers. significantly higher (HR 2.91, = 0.0005) after adjustment year, ESRD, number visits. CONCLUSION Patients have frequency-matched controls, independent multiple covariates. is important comorbidity clinicians recognize because it mortality.