Nicotine enhances the expression of a conditioned place preference in adult male rats

摘要: As the number of cigarette-related deaths has risen over years, researchers have tried to study and understand cigarettes, their components, why they are so addictive despite widespread knowledge potentially fatal health consequences. Research in recent decades unveiled that strength cigarette addiction could be due part primary reinforcing effects nicotine. Although these findings may give medical professionals some answers about this addiction, it does not provide whole picture. conducted more recently shown reinforcement-enhancing effect, a property nicotine increases an organism’s behavior response environmental stimulus, also play large role tobacco addiction. Though many studies observed phenomenon operant paradigm, effect yet using different model. The present hypothesized produced conditioned place preference (CPP) paradigm. Animals were prefer one two chambers either sucrose or cocaine reward. day after post-conditioning test, one-time, acute injection on expressed CPPs was then observed. Results showed significant expression both with animals spending time reward-associated chamber relative first test third preceded by saline injection. Furthermore, there no difference between results injection-free tests. These show can classical conditioning They non-operant previous exposure drug. insight into caused experience