作者: Eva H. Mørkved
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摘要: 2-(N-Cyclohexyl)aminopyridine 1 was reported to form a 1,2-dihydropyridine derivative with carbonyl chloride [4]. This implies that the pyridine nitrogen of is stronger nucleophile than exocyclic nitrogen. Presently found react electrophiles, including chloride, derivatives at 1. proven by relating structures these compounds 2-(N-alkoxycarbonyl-N-cyclohexyl)aminopyridine 1-oxides 5. Compounds 5 were prepared two independent routes, thus proving structure 1H n.m.r. and 13C spectra also support assigned structures.