Roles of chemokines in renal ischemia/reperfusion injury

摘要: Ischemia-reperfusion injury (IR) is a common and an important clinical cause of renal disease, such as transplantation, artery stenosis following shock from any cause. Inflammatory reaction after IR regulated by various kinds mediators. Chemokines are major mediators the inflammation, regulate pro-inflammatory cytokine adhesion molecule expression, leukocyte infiltration activation. key players angiogenesis fibrosis. These inflammatory processes mediated chemokines were observed in not only experimental animal models, but also human diseases with ischemic injury. A number challenges chemokine targeted therapy trying to prevent injury, will give some beneficial effect on