WWP1 as a potential tumor oncogene regulates PTEN-Akt signaling pathway in human gastric carcinoma

摘要: Whelming evidence has demonstrated that WW domain containing E3 ubiquitin protein ligase 1 (WWP1) participates in a wide variety of biological processes and is tightly related to the initiation progression many tumors. Currently, although mounting supports role WWP1 tumor promotion tumorigenesis, potential roles its functions gastric carcinoma are not fully understood. Here, we found messenger RNA (mRNA) were highly expressed tissues cells. High mRNA levels differentiation status, TNM stage, invasive depth, lymph node metastasis, poor prognosis carcinoma. Furthermore, siRNA significantly decreased level MKN-45 AGS cells; meanwhile, depletion markedly inhibited proliferation vitro vivo, arrested cell cycle at G0/G1 phase, induced apoptosis Most notably, downregulation both inactivated PTEN-Akt signaling pathway Taken altogether, our findings suggest acts as an oncogenic factor should be considered novel interfering molecular target for