Imaging of Anticancer Drugs for Therapeutic Response and Prognosis

作者: David J Yang , Chun Li , E Edmund Kim , None

DOI: 10.1007/978-1-4757-3505-5_16

关键词:

摘要: To diagnose cancer, mammography is usually performed in patients with breast cancer; however, the detection rate low among younger women because of their denser tissue. Computed tomography (CT), magnetic resonance imaging (MRI), and ultrasound provide anatomical information but not functional about cancer. These modalities also are helpful assessing or predicting therapeutic response. Thus, to develop an technique predict responsiveness tumors chemotherapy for individual would be most helpful. Drug targeting through a receptor enzymaticmediated process effective way cellselective drug delivery this allows satisfactory transport as well ligand-dependent cell specificity.

参考文章(69)
Michael J. Spinella, Kevin E. Brigle, Sarah J. Freemantle, Esteban E. Sierra, I.David Goldman, Comparison of methotrexate polyglutamylation in L1210 leukemia cells when influx is mediated by the reduced folate carrier or the folate receptor. Lack of evidence for influx route-specific effects. Biochemical Pharmacology. ,vol. 52, pp. 703- 712 ,(1996) , 10.1016/0006-2952(96)00347-4
J Gehl, M Boesgaard, T Paaske, B V Jensen, P Dombernowsky, Paclitaxel and doxorubicin in metastatic breast cancer Seminars in Oncology. ,vol. 23, pp. 35- 38 ,(1996)
Rowan T. Chlebowski, Lovell A. Jones, Jeanne M. Connolly, Ernst L. Wynder, David P. Rose, Effects of tamoxifen adjuvant therapy and a low-fat diet on serum binding proteins and estradiol bioavailability in postmenopausal breast cancer patients. Cancer Research. ,vol. 52, pp. 5386- 5390 ,(1992)
Michael C. Perry, The Chemotherapy Source Book ,(2001)
Steven A. Rosenberg, Vincent T. DeVita, Samuel Hellman, Cancer : Principles and Practice of Oncology ,(1982)
Tania A. Jones, William D. Foulkes, Ian G. Campbell, John Trowsdale, Folate-binding Protein Is a Marker for Ovarian Cancer Cancer Research. ,vol. 51, pp. 5329- 5338 ,(1991)
C.I. Diamanti, C.F. Meares, H.D. Fawcett, J.E. Baumert, R.L. Goode, D.J. Sartoris, L.H. DeRiemer, R.L. Lantieri, D.A. Goodwin, Clinical studies with In-111 BLEDTA, a tumor-imaging conjugate of bleomycin with a bifunctional chelating agent. The Journal of Nuclear Medicine. ,vol. 22, pp. 787- 792 ,(1981)
J H Schornagel, R A Forsch, H M Pinedo, G J Peters, A Rosowsky, J B Hynes, F T Boyle, I Kathmann, A L Jackman, G R Westerhof, Carrier- and receptor-mediated transport of folate antagonists targeting folate-dependent enzymes: correlates of molecular-structure and biological activity Molecular Pharmacology. ,vol. 48, pp. 459- 471 ,(1995)