Trypanosome resistance to human innate immunity: targeting Achilles' heel.
作者： Natalie A. Stephens , Rudo Kieft , Annette MacLeod , Stephen L. Hajduk
关键词:
摘要: Trypanosome lytic factors (TLFs) are powerful, naturally occurring toxins in humans that provide sterile protection against infection by several African trypanosomes. These trypanocidal complexes predominantly enter the parasite binding to trypanosome haptoglobin/hemoglobin receptor (HpHbR), trafficking lysosome, causing membrane damage and, ultimately, cell lysis. Despite TLF-mediated immunity, parasites cause human Trypanosomiasis (HAT), Trypanosoma brucei rhodesiense and gambiense, have developed independent mechanisms of resistance TLF killing. In this review we describe defenses allow infections discuss how targeting these apparent strengths may reveal their Achilles' heel, leading new approaches treatment HAT.
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