Heterogeneity of triple-negative breast cancer: histologic subtyping to inform the outcome.

摘要: Abstract Background This study assesses outcome in terms of disease-free survival (DFS) and overall (OS) special types triple-negative breast cancer (TNBC). Patients Methods We identified 8801 women with first primary nonmetastatic operated on at the European Institute Oncology between 1997 2005. Of these patients, 781 consecutive patients immunohistochemically defined TNBC were selected for analyses. explored patterns recurrence by histologic type. Median follow-up was 5.7 years (range 0-13 years). Results The 5-year DFS 77% TNBC, 68% human epidermal growth factor receptor 2 (HER2)-positive cancer, 84% 95% luminal B A respectively. From subtypes, 693 cases (89%) classified as ductal not otherwise specified (NOS) (invasive carcinoma [IDC]), 29 apocrine (3.7%), 18 (2.3%) lobular, 10 (1.2%) adenoid cystic, metaplastic. Five-year OS carcinoma, 56% 89% metaplastic both 100% cystic medullary carcinomas, Conclusion Distinct prognostic implications may derive from specific histotype TNBC. identification has a significant clinical utility should be considered therapeutic algorithms.