Is Gout Related to an Alteration of the Uric Acid Protein Binding?
作者： Taddeo Anna , Morozzi Gabriella , Marcolongo Roberto
DOI: 10.1007/978-1-4684-5673-8_37
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摘要: For more than a century, increased serum uric acid (U.A.) levels have been known to be risk factor for gout1. However, although many hyperuricemic subjects U.A. concentrations that exceed the estimate solubility of urate in serum, only about 25% them appear develop clinical gout2.
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M.W. Whitehouse, I. Kippen, J.R. Klinenberg, Biochemical properties of anti-inflammatory drugs—XII: Inhibition of urate binding to human albumin by salicylate and phenylbutazone analogues and some novel anti-inflammatory drugs Biochemical Pharmacology. ,vol. 20, pp. 3309- 3320 ,(1971) , 10.1016/0006-2952(71)90435-7
PETER A. SIMKIN, The Pathogenesis of Podagra Annals of Internal Medicine. ,vol. 86, pp. 230- 233 ,(1977) , 10.7326/0003-4819-86-2-230
R. Bluestone, I. Kippen, J. R. Klinenberg, Effect of drugs on urate binding to plasma proteins BMJ. ,vol. 4, pp. 590- 593 ,(1969) , 10.1136/BMJ.4.5683.590
Margaret J. Maclachlan, Gerald P. Rodnan, Effects of food, fast and alcohol on serum uric acid and acute attacks of gout The American Journal of Medicine. ,vol. 42, pp. 38- 57 ,(1967) , 10.1016/0002-9343(67)90005-8
Edward W. Campion, Robert J. Glynn, Lorraine O. Delabry, Asymptomatic hyperuricemia. Risks and consequences in the Normative Aging Study. The American Journal of Medicine. ,vol. 82, pp. 421- 426 ,(1987) , 10.1016/0002-9343(87)90441-4
JAMES R. KLINENBERG, Urate Deposition Disease Annals of Internal Medicine. ,vol. 78, pp. 99- 111 ,(1973) , 10.7326/0003-4819-78-1-99
J. O. Alvsaker, Uric Acid in Human Plasma IV. Investigations on the Interactions Between Urate and the Macromolecular Fraction in Plasma from Healthy Individuals and Patients with Diseases Associated with Hyperuricemia Scandinavian Journal of Clinical & Laboratory Investigation. ,vol. 17, pp. 476- 482 ,(1965) , 10.1080/00365516509075362
M.W. Whitehouse, BIOCHEMICAL PROPERTIES OF ANTI-INFLAMMATORY DRUGS--III. UNCOUPLING OF OXIDATIVE PHOSPHORYLATION IN A CONNECTIVE TISSUE (CARTILAGE) AND LIVER MITOCHONDRIA BY SALICYLATE ANALOGUES: RELATIONSHIP OF STRUCTURE TO ACTIVITY. Biochemical Pharmacology. ,vol. 13, pp. 319- 336 ,(1965) , 10.1016/0006-2952(64)90148-0
Whitehouse Mw, Klinenberg, Bluestone R, Kippen I, Effect of some uricosuric and anti-inflammatory drugs on the binding of uric acid to human serum albumin in vitro. Journal of Laboratory and Clinical Medicine. ,vol. 76, pp. 85- 91 ,(1970)
I Kippen, J R Klinenberg, The binding of urate to plasma proteins determined by means of equilibrium dialysis. Journal of Laboratory and Clinical Medicine. ,vol. 75, pp. 503- 510 ,(1970)