Clinical and immunological parameters of Sjögren's syndrome

摘要: Sjogren's syndrome (SS) is a chronic autoimmune disease that primarily affects the exocrine glands, resulting in their functional impairment. In SS, lymphocytic infiltration of salivary and lacrimal deposition several types autoantibodies, mainly anti-SS-A (anti-Ro) anti-SS-B (anti-La), lead to inflammation, with xerostomia keratoconjunctivitis sicca. its primary form (pSS), SS does not involve additional connective tissue diseases, whereas secondary more common (sSS), presents association other rheumatic rheumatoid arthritis (RA), systemic lupus erythematosus (SLE) sclerosis (SSc). As most environmental, hormonal genetic factors are implicated pathogenesis. T cells predominate mild lesions, B advanced lesions. Th1, Th2, Th17, follicular helper (Tfh) regulatory (Tregs/Bregs), characteristic cytokine profiles, have been pathogenesis SS. It has suggested Th1 Th17 initiate and, as progresses, Th2 Tfh predominate. assumed that, all inflammatory conditions, tolerance defects contribute intriguing it remains unclear which whether they ameliorate or worsen disease. this review we present comprehensive update on emphasis immune system involvement, suggest new insights into immunopathogenesis.