Modulation of flavocoenzyme levels in rat tissues by N-nitrosodiethylamine.
作者： V.S. Aboobaker , R.K. Bhattacharya
DOI: 10.1016/0304-3835(89)90056-6
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摘要: The hepatocarcinogen N-nitrosodiethylamine (NDEA) was administered continuously in drinking water (200 mg/l) to male Wistar rats, and at intervals tissues were examined for flavocoenzyme levels. Flavin adenine dinucleotide (FAD) non-FAD riboflavin determined fluorimetrically. Results revealed significant depletion hepatic levels of these compounds the end 60 days, a period exposure considered adequate development hepatoma. Considerable reduction also noticed after 15 when lower dose NDEA (50 mg/l). flavin liver short remained depleted even withdrawal carcinogen. Changes kidney found be less significant. selective target tissue following is significance, may related biochemical mechanisms involved malignant transformation.
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