Influence of Phospholipids of the Platelet Membrane of Newborns on the Thrombin Generation

作者: M. Petritsch , G. Cvirn , B. Leschnik , M. Köstenberger , W. Muntean

DOI: 10.1007/978-3-642-18150-4_35

关键词:

摘要: Newborns have despite of low clotting factors and an in vitro poor platelet function a good functioning hemostasis. The reason for that is still not completely clear. Platelet counts healthy neonates are similar to those normal adults, but their platelets react hyporesponsively variety physiological agonists, resulting decreased activation aggregation [1–4].

参考文章(13)
Peter W. Reed, Henry A. Lardy, A23187: A Divalent Cation Ionophore Journal of Biological Chemistry. ,vol. 247, pp. 6970- 6977 ,(1972) , 10.1016/S0021-9258(19)44681-4
M Andrew, B Paes, R Milner, M Johnston, L Mitchell, DM Tollefsen, P Powers, Development of the human coagulation system in the full-term infant Blood. ,vol. 70, pp. 165- 172 ,(1987) , 10.1182/BLOOD.V70.1.165.165
Arthur L. Bloom, Duncan P. Thomas, Haemostasis and thrombosis Churchill Livingstone. ,(1987)
Edouard M. Bevers, Roland H. J. Tilly, Joan M. G. Senden, Paul Comfurius, Robert F. A. Zwaal, Exposure of endogenous phosphatidylserine at the outer surface of stimulated platelets is reversed by restoration of aminophospholipid translocase activity. Biochemistry. ,vol. 28, pp. 2382- 2387 ,(1989) , 10.1021/BI00432A007
Edouard M. BEVERS, Paul COMFURIUS, Jan L. M. L. VAN RIJN, H. Coenraad HEMKER, Generation of prothrombin-converting activity and the exposure of phosphatidylserine at the outer surface of platelets. FEBS Journal. ,vol. 122, pp. 429- 436 ,(1982) , 10.1111/J.1432-1033.1982.TB05898.X
Sara J Israels, Michele Daniels, Eileen M Mcmillan, Deficient Collagen-Induced Activation in the Newborn Platelet Pediatric Research. ,vol. 27, pp. 337- 343 ,(1990) , 10.1203/00006450-199004000-00004
Beth Gelman, BN Setty, Dechun Chen, Soheil Amin-Hanjani, Marie J Stuart, Impaired mobilization of intracellular calcium in neonatal platelets Pediatric Research. ,vol. 39, pp. 692- 696 ,(1996) , 10.1203/00006450-199604000-00022
Maureen Andrew, Valerie Castle, Lesley Mitchell, Bosco Paes, Modified bleeding time in the infant. American Journal of Hematology. ,vol. 30, pp. 190- 191 ,(1989) , 10.1002/AJH.2830300314
Damodara Rajasekhar, Anita S Kestin, Francis J Bednarek, Patricia A Ellis, Marc R Barnard, Alan D Michelson, Neonatal platelets are less reactive than adult platelets to physiological agonists in whole blood. Thrombosis and Haemostasis. ,vol. 72, pp. 957- 963 ,(1994) , 10.1055/S-0038-1648990
Maureen Andrew, Barbara Schmidt, Lesley Mitchell, Bosco Paes, Frederick Ofosu, Thrombin generation in newborn plasma is critically dependent on the concentration of prothrombin. Thrombosis and Haemostasis. ,vol. 63, pp. 27- 30 ,(1990) , 10.1055/S-0038-1645680