Morphogenesis of Pulmonary Veno-Occlusive Disease in a Newborn: Image Analysis Study

摘要: Summary A 9-day-old girl was admitted to hospital because of respiratory distress. The died on the 11th day life shortly after an haemodynamic study and autopsy disclosed a pulmonary veno-occlusive disease with lesions in relatively early stages development. Morphological pattern computerized image analysis data induce rule out thrombosis as previous event development fibrotic changes point "primary" intimal involvement, presumably triggered by endothelial injury, determining myxoid change intima leading cellular proliferation ultimate occlusion small veins. Apparently progress from smaller veins larger ones, which involvement is focal character related openings collateral branches. homogeneous more recent contrast heterogeneity process ones.