Mucin-Grafted Polyethylene Glycol Microparticles Enable Oral Insulin Delivery for Improving Diabetic Treatment
作者： Momoh A. Mumuni , Ugwu E. Calister , Nafiu Aminu , Kenechukwu C. Franklin , Adedokun Musiliu Oluseun
DOI: 10.3390/APP10082649
关键词:
摘要: In this study, different ratios of mucin-grafted polyethylene-glycol-based microparticles were prepared and evaluated both in vitro vivo as carriers for the oral delivery insulin. Characterization measurements showed that insulin-loaded display irregular porosity shape. The encapsulation efficiency loading capacity insulin >82% 18%, respectively. release varied between 68% 92% depending on microparticle formulation. particular, orally administered resulted a significant fall blood glucose levels, compared to solution. Subcutaneous administration faster, albeit not sustained, within short time polymeric microparticle-based formulations. These results indicate possible using combination polymers.
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