Studies of depression-related states in animal models of Parkinsonism.

摘要: The diagnosis of Parkinson's disease (PD) is solely based on movement disorders, but several non-motor deficits are common in PD. Depression often precedes the dysfunctions and continues to be a major concern during all stages disease. pathophysiology parkinsonian depression largely unknown, appears partly differ from patients without Because increased awareness negative impact quality life PD patients, there growing interest developing animal models parkinsonism that also recapitulate depressive-like symptomatology. This review introduces paradigms for measurement depression-like behaviors rodents summarizes data behavioral, neurochemical pharmacological changes experimental with relevance depression-related states.