Real-world impact of neurocognitive deficits in acute and early HIV infection.

摘要: The acute and early period of HIV-1 infection (AEH) is characterized by neuroinflammatory immunopathogenic processes that can alter the integrity neural systems neurocognitive functions. However, extent to which central nervous system changes in AEH confer increased risk real-world functioning (RWF) problems not known. In present study, 34 individuals with 39 seronegative comparison participants completed standardized neuromedical, psychiatric, research evaluations, alongside a comprehensive assessment RWF included cognitive symptoms daily life, basic instrumental activities living, clinician-rated global functioning, employment. Results showed was associated significantly dependence RWF, particularly elevated among persons impairment (NCI). Among those AEH, NCI (i.e., deficits learning information processing speed), mood disorders Bipolar Disorder), substance (e.g., methamphetamine dependence) were all independently predictive dependence. Findings suggest neurocognitively impaired are at notably clinically significant challenges normal functioning. Screening for neurocognitive, mood, use may facilitate identification high functional who benefit from psychological medical strategies manage their neuropsychiatric conditions.