IL-17 in Severe Asthma. Where Do We Stand?

摘要: Asthma is a major chronic disease ranging from mild to severe refractory and classified into various clinical phenotypes. Severe asthma difficult treat frequently requires high doses of systemic steroids. In some cases, even responds poorly Several studies have suggested central role IL-17 (also called IL-17A) in asthma. Indeed, levels are found induced sputum bronchial biopsies obtained patients with The recent identification steroid-insensitive pathogenic Th17 pathway therefore interest. addition, IL-17A has been described multiple aspects pathogenesis, including structural alterations epithelial cells smooth muscle contraction. this perspective article, we frame the topic effects by reviewing updated information human studies. We summarize discuss implications induction neutrophilic airway inflammation,...