Canceromics Studies Unravel Tumor’s Glutamine Addiction After Metabolic Reprogramming

摘要: Metabolism is fundamental to cell survival, growth, and behavior. Tumor cells have an enhanced demand for nutrients which provide biosynthetic building blocks cellular energy sustain their proliferative status. Altered metabolism a hallmark of cancer. The term metabolic reprogramming has been coined describe the whole range abnormalities accompanying tumorigenesis metastasis. Increased glutamine uptake glutaminolysis are key traits that consistently found on wide human experimental cancers. Glutaminase proteins control first step in glutaminolytic process: conversion glutamate ammonium ions. expression correlated with malignancy growth rate great variety tumors. Recent works now starting uncover differential glutaminase isoenzymes regulation by oncogenes tumor suppressor genes. In parallel, isoforms attracting interest as novel cancer chemotherapeutic targets. focus this chapter will highlight role addiction biology particular emphasis interaction between host tumor.