Aldolase as a chirality intersection of L-amino acids and D-sugars.

摘要: Aldolase plays an important role in glycolysis and gluconeogenesis to produce D-fructose-1,6-bisphosphate (D-FBP) from dihydroxyacetone phosphate (DHP) D-glyceraldehyde-3-phosphate (D-GAP). This reaction is stereoselective retains the D-GAP 2R configuration yields D-FBP (with configuration: 3S, 4S, 5R). The 3- 4-position carbons are newly formed chiral because 5-position carbon of comes 2-position D-GAP. Although four diastereomeric products, (3S, 4R, 5R), (3R, expected nonenzymatic reaction, only 5R) diastereomer obtained. Therefore, chirality 4-positions induced by enzyme composed L-amino acid residues. D-Glucose-6-phosphate (D-G6P), which generated pathway, produces D-ribose-5-phosphate (D-R5P) pentose pathway. D-R5P converted PRPP (5-phosphoribosyl-α-pyrophosphate), used for de novo synthesis nucleotides. Ribonucleic (RNA) uses nucleotides as building blocks. configurations 4R-carbon 3S-carbon retained. stereochemical structure RNA based on 3S well 4R (D). consideration above suggests that aldolase a key determines D-R5P. It thus intersection between amino acids sugars, sugar determined environment protein, aldolase, D-FBP.